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Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 471-479 doi: 10.1007/s11684-017-0602-z

Abstract:

Several universal influenza virus vaccine candidates based on eliciting antibodies against the hemagglutininwhat is known about the human humoral immune response to vaccination and infection with H7 subtype influenzabetter understanding of this phenomenon and the underlying mechanisms might help to develop future universalinfluenza virus vaccine candidates.

Keywords： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in

Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 149-159 doi: 10.1007/s11684-020-0764-y

Abstract: Influenza causes seasonal outbreaks yearly and unpredictable pandemics with high morbidity and mortalityvirus strains and the rapid emergence of drug-resistant variants.Moreover, designing a universal influenza vaccine that is sufficiently immunogenic to induce universalThese findings may have important implications for the development of universal influenza vaccines andvirus to promote the development of universal anti-influenza antibodies or vaccines and extend the discovery

Keywords： influenza virus     neutralizing antibody     hemagglutinin     globular head region     trimeric interface    

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Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic

William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 507-527 doi: 10.1007/s11684-020-0814-5

Abstract: The avian influenza A (H7N9) virus is a zoonotic virus that is closely associated with live poultry marketsFive waves of the H7N9 influenza epidemic occurred in China between March 2013 and September 2017.H7N9 with low-pathogenicity dominated in the first four waves, whereas highly pathogenic H7N9 influenzaand other countries responded quickly, controlled the epidemic well thus far, and characterized the virusfeatures, virulence and pathogenesis, receptor binding, T-cell responses, monoclonal antibody development, vaccine

Keywords： H7N9     HPAIV     epidemiology     clinical features     pathogenesis     hemagglutinin     immunity     vaccine    

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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:implications in vaccine design

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract:

Superinfection is frequently detected among individuals infected by human immunodeficiency virus typeThus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses thanif superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine

Keywords： human immunodeficiency virus type I     superinfection     incidence     immune response    

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Assessment of vaccination strategies against highly pathogenic avian influenza in China

Honglei SUN,Jinhua LIU

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 277-281 doi: 10.15302/J-FASE-2014036

Abstract: Vaccination for highly pathogenic avian influenza (HPAI) has been implemented in China for a decade,however, the virus is still present in poultry.

Keywords： highly pathogenic avian influenza     vaccine     vaccination     control    

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Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 984-990 doi: 10.1007/s11684-022-0930-5

Abstract: control the spread of the coronavirus disease 2019 (COVID-19), resulting in a worldwide decline in influenzaHowever, the influenza risk in China warrants cautious assessment.Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains.A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenzaIncreasing vaccination rates and maintaining NPIs are recommended to prevent an elevated influenza risk

Keywords： influenza virus     seroprevalence     antibody     COVID-19     cross-sectional study    

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Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management

Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 147-156 doi: 10.1007/s11684-010-0030-9

Abstract: The pandemic H1N1 2009 influenza virus has caused the first influenza pandemic of the 21st century, leading

Keywords： influenza A virus     H1N1 subtype     pandemic     pathogenesis     virulence factors     immunity     management     antiviral    

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Research progress on human infection with avian influenza H7N9

Xiaoxin Wu, Lanlan Xiao, Lanjuan Li

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 8-20 doi: 10.1007/s11684-020-0739-z

Abstract: Meanwhile, the H7N9 virus continues to accumulate mutations, and its affinity for the human respiratorythe past 6 years, we have accumulated rich experience in dealing with H7N9, especially in terms of virusepidemiological research, key site mutation monitoring, critical disease mechanisms, clinical treatment, and vaccinewe reviewed the clinical and epidemiological characteristics of H7N9, the key gene mutations of the virus, and H7N9 vaccine, thus providing a scientific basis for further monitoring and prevention of H7N9 influenza

Keywords： H7N9     pandemic     epidemiology     mutations     vaccine     influenza    

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Research and development of a novel subunit vaccine for the currently circulating pseudorabies virus

Yuzhou WANG,Tongyan WANG,He YAN,Fanli YANG,Linghua GUO,Qingyuan YANG,Xule HU,Feifei TAN,Yan XIAO,Xiangdong LI,Kegong TIAN

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 3,   Pages 216-222 doi: 10.15302/J-FASE-2015072

Abstract: Commercial gE-deleted live pseudorabies virus (PRV) vaccine has been widely used to control this diseaseSeveral killed and live vaccine candidates based on current PRV variants have been reported to be effectiveA subunit vaccine based on gB protein, one major PRV glycoprotein which elicits strong humoral and cellularin baculovirus/insect cells in the soluble format and was tested on 3-week-old piglets as a subunit vaccineHence, this novel gB-based vaccine could be applied as an effective subunit vaccine to control PRV variant

Keywords： pseudorabies virus     glycoprotein B protein     subunit vaccine    

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Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 390-395 doi: 10.1007/s11684-009-0087-5

Abstract: We constructed a eukaryotic expression plasmid encoding Epstein-Barr virus latent membrane protein 2It was employed to evaluate immune response of the mice inoculated doubly with the DNA vaccine.The serum titer of IgG antibody against LMP2 epitope in the mice immunized with the DNA vaccine encodingIn conclusion, the EBV DNA vaccine can induce a strong humoral immune response in mice.

Keywords： Epstein-Barr virus     latent membrane protein 2     nasopharyngeal carcinoma     humoral immunity    

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i>RR1 and RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies virusvaccine candidate in natural pig host

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 81-86 doi: 10.15302/J-FASE-2016088

Abstract: encode the small subunit and large subunit of viral ribonucleotide reductase (RR) in pseudorabies virusIn this study, we deleted and genes based on a / / triple gene-deleted pseudorabies virus and testedits efficacy in pigs as a vaccine candidate.The rescued virus showed similar growth properties and plaque size as its parent strain.antibodies and virus neutralizing antibodies.

Keywords： pseudorabies virus     RR1 and RR2     ribonucleotide reductase     vaccine candidate    

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Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry

Jiao HU,Xiufan LIU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 11-24 doi: 10.15302/J-FASE-2016092

Abstract: The H9N2 and H5N1 avian influenza viruses (AIVs) have been circulating in poultry in China and becomeendemicity makes them actively involved in the emergence of the novel lineages of other subtypes of influenzaviruses, such as the well-known viruses of the highly pathogenic avian influenza (HPAI) H5N2 and the

Keywords： avian influenza virus     H9N2     H5N1     novel viruses     public health    

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The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 333-344 doi: 10.1007/s11684-013-0275-1

Abstract:

This study reports the first death caused by a novel avian influenza A (H7N9) virus in Zhejiang ProvinceThe patient initially complained of diarrhea and influenza-like symptoms on March 7 and 14 respectivelyThis H7N9 virus from Zhejiang is highly similar to isolates obtained from Shanghai, Jiangsu, Anhui, etcOnly two health workers presented with influenza-like symptoms, and they subsequently tested negativePerson-to-person transmission of the H7N9 virus was not detected among close contacts, but such transmission

Keywords： avian influenza A (H7N9) virus     epidemiology     contacts     person-to-person transmission    

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COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-Spectrum Protection Against Influenza Article

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Engineering 2024, Volume 32, Issue 1,   Pages 42-57 doi: 10.1016/j.eng.2023.08.001

Abstract:

A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reducedeffectiveness of current influenza vaccines.virus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into thedelivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virusThis discovery revolutionizes influenza vaccine design and delivery; Salmonella-mediated COBRA-HA1

Keywords： COBRA     Influenza A     Salmonella     Vaccine     Broad spectral protection    

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Innovation-driven trend shaping COVID-19 vaccine development in China

Frontiers of Medicine doi: 10.1007/s11684-023-1034-6

Abstract: from collaborated researches, vaccines based on the spike protein of SARS-CoV-2 or inactivated whole viruswe outline representative vaccines in multiple routes, while the merits and plights of the existing vaccinetraditional routes, the discovery of innovative approach to developing effective vaccines based on virus

Keywords： SARS-CoV-2     COVID-19 vaccine     vaccine development    

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Title Author Date Type Operation

Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Journal Article

Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in

Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying

Journal Article

Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic

William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu

Journal Article

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:implications in vaccine design

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article

Assessment of vaccination strategies against highly pathogenic avian influenza in China

Honglei SUN,Jinhua LIU

Journal Article

Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

Journal Article

Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management

Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,

Journal Article

Research progress on human infection with avian influenza H7N9

Xiaoxin Wu, Lanlan Xiao, Lanjuan Li

Journal Article

Research and development of a novel subunit vaccine for the currently circulating pseudorabies virus

Yuzhou WANG,Tongyan WANG,He YAN,Fanli YANG,Linghua GUO,Qingyuan YANG,Xule HU,Feifei TAN,Yan XIAO,Xiangdong LI,Kegong TIAN

Journal Article

Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Journal Article

i>RR1 and RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies virusvaccine candidate in natural pig host

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Journal Article

Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry

Jiao HU,Xiufan LIU

Journal Article

The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report

Enfu Chen, Fenjuan Wang, Huakun Lv, Yanjun Zhang, Hua Ding, Shelan Liu, Jian Cai, Li Xie, Xiaoping Xu, Chengliang Chai, Haiyan Mao, Jimin Sun, Junfen Lin, Zhao Yu, Lianhong Li, Zhiping Chen, Shichang Xia

Journal Article

COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-Spectrum Protection Against Influenza

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Journal Article

Innovation-driven trend shaping COVID-19 vaccine development in China

Journal Article